lecture title

the interaction between follicular helper t cells and dendritic cells drives the development of chronic colitis

lecture time

december 19, 2024 14:00-17:00

lecture location

conference room 402, building 5, jinfeng laboratory

speaker

white snow

introduction to the speaker

white snow, currently works at shanghai immunotherapy innovation research institute as an assistant researcher. he graduated from china medical university with a bachelor's degree and a doctoral degree, and then completed postdoctoral work at tsinghua university school of medicine. his co-supervisor was academician dong chen. research areas mainly include inflammatory bowel disease and autoimmune diseases. representative articles are mainly published in journals such as nature immunology, and he has hosted scientific research projects such as the national natural science foundation of china youth fund.

lecture introduction

the immunological mechanisms of chronic colitis have not been fully elucidated. t follicular helper cells (tfh cells) are well known for their unique role in promoting b cell activation and antibody production in germinal center reactions. this study reveals a new function of tfh cells in chronic colitis. tfh cells initially participate in the aggregation of dendritic cells (dc) and t cells in the t cell area to form dc-t cell clusters. subsequently, these tfh cells further differentiate into long-lived pathogenic th1 cells, which promote the pathological process of colitis. . our study extends the function of tfh cells from their traditional role in supporting b cells in germinal centers to their interaction with dendritic cells in chronic inflammatory settings and promoting the occurrence of colitis.